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Ipamorelin emerged from this programme as the first truly selective GHS-R1a agonist , a pentapeptide incorporating alpha-aminoisobutyric acid (Aib) at position 1, His at position 2, the unnatural D-2-naphthylalanine residue at position 3, D-Phe at position 4, and C-terminal Lys-NH2 and a structural solution that achieves high-affinity GHS-R1a binding and potent GH release while eliminating the receptor interactions responsible for prolactin and cortisol co-stimulation in non-selective first-generation GH secretagogues
On top of that, new indications, such as treating MASH or cardiovascular disease, could extend this exclusivity further, just like tirzepatides recent obesity approval will likely extend its control in that market
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By managing the dosage of GLP-1 medications and ensuring adequate protein consumption, patients can maintain or even increase their muscle mass while using these drugs
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