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OgawaSIshikiMNakoKOkamuraMSendaMMoriTet al

Semaglutide undergoes enzymatic degradation similar to naturally occurring peptides, while most antidepressants are metabolized through cytochrome P450 enzymes

The proproliferative effects of GLP-1 RAs on gastrointestinal tissues have been questioned in preclinical studies, although their anti-inflammatory and metabolic properties suggest a protective role [40]

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In contrast, the K265G and the double K265G/K301G mutants severely impaired metabolic activity and cell viability, whereas the patient-derived E366G mutation caused only a moderate reduction of both (Fig