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Higher doses are associated with more frequent digestive problems, including nausea

Compounded medications - including compounded semaglutide and compounded tirzepatide - are prepared by licensed compounding pharmacies when legally permissible, such as for specific patient needs or certain shortage-related circumstances

Phentermine-topiramate combinations (Qsymia) carry more substantial concerns, as topiramate can reduce contraceptive steroid levels through enzyme induction, potentially increasing breakthrough bleeding and reducing efficacy, particularly at higher doses

[24] to as many as 1648 in the study by Marso et al

This medication works by mimicking the action of the naturally occurring hormone GLP-1, which stimulates insulin secretion in a glucose-dependent manner, suppresses glucagon release, slows gastric emptying, and reduces appetite through central nervous system pathways