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Based on this, in the future, encapsulating GLP-1 analogs within vitamin A-modified liposomes, while simultaneously targeting HSCs and leveraging the anti-inflammatory and metabolic regulatory effects of GLP-1 analogs, is expected to synergistically reduce HSC activation and improve the hepatic metabolic environment, thus offering a more promising innovative therapy for NASH and related liver fibrosis [254, 255]
NICE guidelines (NG28) recommend GLP-1 receptor agonists for type 2 diabetes based on individual patient factors, including cardiovascular risk, and not strictly as second- or third-line therapy after metformin failure
The mean age in the matched cohorts was 52.4 years, with the population comprising 55.6% females and 61% Whites
Smaller meals and simpler foods often help, especially around dose increases