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The severity of nausea may be reduced by starting with lower doses and gradually titrating upward, eating smaller meals, avoiding high-fat foods, and maintaining adequate hydration

[13] [14] This cardiovascular profile has been extensively studied, with certain agents (liraglutide, semaglutide, dulaglutide) demonstrating cardiovascular outcome benefits in patients with established cardiovascular disease or multiple risk factors

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Quantification of 2HG enantiomers 2HG quantification in SCD erythroblasts was performed as we previously described 24 by liquid chromatographymass spectrometry (LC-MS/MS) after derivatization using N-(p-Toluenesulfonyl)-L-phenylalanyl Chloride (TSPC) on the LC-ESI-MS/MS system