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One technique that allows selective downregulation of a specific pathway involves antisense oligonucleotides

The age-related decline in neuromodulators, neurotransmitters, and glutathione levels may account for the diminished cognitive benefits of caffeine and paraxanthine in older animals

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Small improvements in specific glutathione and behavioral measures occurred over the study period for all groups

National Center for Complementary and Integrative Health notes that randomized, placebo-controlled trials are the gold standard because they help determine whether apparent improvement is due to the treatment or to chance