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These pathways include those related to oxidative stress and inflammation, lipid metabolism, GLUT4 expression and translocation, and the SIRT1/AMPK signaling axis (251)

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Analysis of data from two 12-week randomized controlled trials in 130 participants with mild or moderate CVD risk found that the consumption of 400 g/week of high-glucosinolate broccoli (containing 3 to 6 times more glucoraphanin and glucoiberin than standard broccoli) resulted in a significant reduction in low-density lipoprotein (LDL)-cholesterol concentration in plasma compared with standard broccoli (29)

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