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Internal pilot work before committing to larger dual-peptide or triple-pathway strategies

The whole process occurs inside melanosomes and begins with the translocation of the enzyme tyrosinase, which catalyzes the oxidation of tyrosine into dihydroxyphenylalanine (DOPA) and subsequently into dopaquinone (DQ) 37 (Fig

Sikiric assured me that the trial had been absolutely successful and that the data would be available very soon, but he declined to let me see it

Additionally, HNK induced the ferroptosis of acute myeloid leukemia (AML) in a non-canonical manner by significantly upregulating HO-1 expression instead of downregulating SLC7A11 expression (Lai et al., 2022)