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Therefore, even though a homeostatic axis whereby meningeal IL-17A release could signal in the cortex through Il17ra was previously proposed 47 , it is tempting to speculate that in AD, IL-1 derived from the brain parenchyma, could also signal back to the meninges, creating a feedback loop that sustains meningeal pT H 17 cells

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KO, n = 3 representative from 2 independent experiments, p = 0.0001) (c)