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In the Phase 2 trial, participants lost up to 24 percent of body weight over 48 weeks at the highest dose

Eli Lilly's TRIUMPH Phase 3 program includes multiple trials recruiting participants at sites across the US and globally

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it is known that obesity is accompanied by macrophage adipose tissue infiltration and macrophages secrete abundant inflammatory cytokines, which affect the metabolism of adipocytes

Resolved with hydration and temporary medication discontinuation