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3 Appendicitis is the most common abdominal surgical emergency worldwide, with significant cost burden on healthcare, and can lead to serious complications, including ileus, peritonitis, abscess, and even death

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These issues then trigger a cascade of pathological events, such as glomerular hyperfiltration, inflammation, oxidative stress, and progressive fibrosis, eventually leading to loss of renal function [18, 19]

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For example, in exploratory trials for Alzheimers disease, a specialized oral formulation of MB (methylthioninium chloride, brand name LMTM) was studied at doses as low as 4 mg twice daily (8 mg total per day) and showed some promise in slowing cognitive decline