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Studies showed that oral semaglutide was well tolerated, with a safety profile consistent with the GLP-1RA drug class
Here, 10% niacinamide is paired with zinc PCA for oil control, n-acetyl glucosamine for gentle exfoliation, and hyaluronic acid for hydration
* very poor solubility in culture medium (drug precipitation) and toxicity against cells
Moreover, preclinical studies of individual peptides have not reported significant acute toxicity
therefore, incorporating easy-to-give characteristics into the product at the development phase removes such uncertainty of outcome
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