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Previous work from our group supports the importance of arterial stiffness as an early-stage biomarker for future decrements in brain structure by showing that high levels of arterial stiffness in midlife, but not age-related arterial stiffening, are predictive of lower grey matter volume and greater white matter hyperintensity burden in a 10-year follow-up ( Cerebrovascular function Optimal function of cerebral conduit arteries is another critical factor in ensuring CBF matches the metabolic demands for brain function and maintain long-term brain health

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