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The study concluded that there could be potential vasculature effects that occurred with the addition of GLP-1 RA

Alternatives include other GLP-1 receptor agonists (such as dulaglutide or liraglutide), SGLT2 inhibitors (such as dapagliflozin or empagliflozin), DPP-4 inhibitors, or insulin therapy

The approval is supported by the OASIS clinical trial programme, where participants achieved around 17% average weight loss, with nearly one in three losing 20% or more, alongside lifestyle intervention

For plateau management, exploring what to do when tirzepatide stops working or troubleshooting semaglutide plateaus may be more productive

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