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Studies have reported that more than 210 gene mutations contribute to the progression of ALS, with mutations in superoxide dismutase 1 (SOD1), fusion sarcoma gene (FUS), TAR DNA binding protein 43 (TDP-43), and other genes being recognized as risk factors for the development of ALS (Smith et al., 2019)

A meta-analysis found a 71% reduction in the risk dysplasia and cancer of the esophagus, while a Danish population-based study with over a decade of follow-up found that patients with the best compliance in taking PPIs had the highest risk of esophageal adenocarcinoma (Hvid-Jensen F, 2014)

It is worth noting that TRL is not always a fixed designation

Hanson, D

Pectin and complications after gastric surgery: normalisation of postprandial glucose and endocrine responses