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6.2 NADPH: driving force for glutathione redox cycling The antioxidant activity of glutathione (GSH) critically relies on its regeneration from the oxidized form, glutathione disulfide (GSSG), through a reaction catalyzed by glutathione reductase (GR) that consumes NADPH

Aboudalle I, Kantarjian HM, Ohanian MN, Alvarado Y, Jabbour EJ, Garcia-Manero G, Naqvi K, Wierda WG, Daver NG, Burger JA, Konopleva MY, Takahashi K, Andreeff M , Pemmaraju N, Ferrajoli A, Borthakur G, Kadia TM, Ravandi F, Cortes JE

Hypoxia decreased 2 key enzyme activities that regulate GSH synthesis, glutamate cysteine ligase (GCL) (E.C