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One study in diet-induced obese mice found that an NNMT inhibitor combined with a calorie-restricted diet was associated with shifts in gut bacterial populations, suggesting metabolic intervention can have knock-on effects on gut composition

The findings supported the broader hypothesis advanced by the Khavinson group across multiple studies that pineal-derived peptide bioregulators can modulate age-related decline in pineal gland function

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pylori without interfering with the physiological microbiota

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