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With respect to the affected toes, there was no distinction if one or more than one joint in the same toe were affected, so the max scored is 1

SARS-CoV-2-infected patients with COVID-19 disease show alterations in the glucoseinsulin axis leading to hyperglycemia, hyperinsulinemia and insulin resistance, increased oxidative/nitrosative stress, and significantly decreased vitamin D, thiols, total-antioxidant-capacity, GSH and selenium (Soto et al., 2022)

Additionally, skeletal muscles are made up of myocytes or fibers consisting of myofibrils

In addition, The 9 mg arm showed a reported mean reduction of 20.1% at 48 weeks under the trials efficacy estimand

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