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Despite these challenges, tirzepatide proved more effective at reducing HbA1c levels than seen in the global SURPASS studies

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A few of the most significant contributors to NAD+ depletion include: CD38: An enzyme that breaks down NAD+ and becomes more active with age, especially in response to inflammation

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This means that it stimulates insulin production only when blood glucose levels are high, thus reducing the risk of hypoglycemia, a common concern with some diabetes treatments