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Levothyroxine dosing is influenced by body weight, with typical maintenance doses ranging from 1.6-1.8 mcg/kg/day based on ideal or lean body weight (using actual body weight in obesity may lead to overreplacement)

Infect Immun 74:11061112

doi: 10.1371/journal.ppat.1009884

PI3K/Akt/mTOR Pathway The PI3K/Akt/mTOR pathway is particularly crucial for IGF-1 LR3's anabolic and metabolic effects

full-length hGH on lipolytic activity IGF-1 independence and selective metabolic effects Cartilage regeneration and joint biology in preclinical models

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