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Cani PD, Montoya ML, Neyrinck AM, Delzenne NM, Lambert DM

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11, 12, 13 However, the LH is in fact the most potent self-stimulation center in the brain, and given that hungry/food-restricted rats self-stimulate even more than fed rats, an interaction between the metabolic status and reward may require processing by this brain nucleus, 7, 14 although it is also possible that stimulation of the median forebrain bundle, which connects the VTA to the NAc and runs through the LH, may contribute to the reinforcing effects of the intracranial self-stimulation studies

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