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Such categorization of interventions mirrors the individual- and system- or structural-level components that have a cumulative effect on AD/ADRD outcomes over the life course (see Figure 1-5)

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There is significant evidence that people with type 2 diabetes in the US, UK and worldwide do not intensify treatment, despite not achieving glycemic control targets, with concerns around potential side effects of therapies (such as weight gain and hypoglycemia) and fear of injection often cited as reasons for therapeutic inertia [18,19,20,21,22]

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