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These data demonstrate that the endogenous de novo carnitine-synthesis pathway provides a non-redundant nuclear pool of acetyl-CoA for histone acetylation, even in the presence of the ACLY nucleo-cytosolic acetyl-CoA-generating pathway (Fig

Starting low and going slow, scheduling follow-up visits after dose adjustment, and offering practical tips for gastrointestinal symptoms all help patients stay on track

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The diagnostic report includes specific recommendations for follow-up therapy and intervention