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Further, deleting GLP-1Rs in ME tanycytes has similar effects [125], suggesting that liraglutide first activates GLP-1Rs in ME tanycytes to then gain access to and activate GLP-1R-expressing hypothalamic neurons and exert its effects on energy balance
Disease-Modifying Perspective: These data support reconceptualising GLP-1RAs not merely as weight-management agents, but as cardiovascular disease-modifying therapies with pleiotropic mechanisms of action
Orlistat: Causes gastrointestinal issues, including oily stools and flatulence
