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Izzo JG, Wu TT, Luthra R, Luthra MG, Swisher S , Aggarwal BB, Bresalier RS, Milas L, Liao Z, Hittelman WN, Ajani J

Infiltrating CCR2 monocytes become pro-inflammatory macrophages, releasing NO, ROS, IL-1, and TNF-, which enhances microglial priming and causes mitochondrial stress in dopaminergic neurons

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