The Dopamine Link: What's Happening in the Brain Experts believe the emotional shift is tied to the brain's dopamine, or reward, system, since GLP-1 receptors are expressed in exactly the circuits linked to reward and pleasure
Jee J-P, Pangeni R, Jha SK et al (2019) Preparation and in vivo evaluation of a topical hydrogel system incorporating highly skin-permeable growth factors, quercetin, and oxygen carriers for enhanced diabetic wound-healing therapy
[DOI] [PubMed] [Google Scholar] 117.Lockie S.H., Heppner K.M., Chaudhary N., Chabenne J.R., Morgan D.A., Veyrat-Durebex C
However comparing GLP-1s to metformin is not straightforward, as individual treatment plans may vary and the choice of medication can depend on various factors
In head-to-head clinical trials, tirzepatide has demonstrated greater average weight loss compared to semaglutide, though individual responses vary