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The treatment policy estimand evaluates the treatment effect for all randomised patients, regardless of trial product discontinuation or the use of rescue medication

Dose reduction or switching to alternative diabetes medications may be considered if reflux remains problematic despite conservative measures

Nummular Dermatitis: This type causes round, coin-shaped patches of irritated skin, often on the arms or legs

Tier 2 conditions in detail: Heart failure with preserved ejection fraction (HFpEF) HFpEF is heart failure with a left ventricular ejection fraction of 50 percent or higher on echocardiogram