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for example, 3 kg weight reduction leads to a marginal improvement in LDL-C and mean reduction in triglycerides of 15 mg/dL, while weight loss of 58 kg, lowers LDL-C on average by 5 mg/dL and increases HDL-C by 3 mg/dL

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Journal reference: Martinelli, S., Mazzotta, A., Longaroni, M., & Petrucciani, N

Exendin-4 and GLP-1 decreases induced expression of ICAM-1, VCAM-1 and RAGE in human retinal pigment epithelial cells

Patients with a personal or family history of medullary thyroid carcinoma or multiple endocrine neoplasia syndrome type 2 should not use GLP-1 medications due to a theoretical risk of thyroid tumors observed in animal studies