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While tirzepatide can be stopped abruptly without medical risk from the medication itself, a thoughtful discontinuation strategy optimizes safety and long-term outcomes

Nutrient levels: B12 and related nutrients are monitored when symptoms indicate deficiency or when long-term weight changes could affect intake or absorption

As patients lose weight, the body undergoes compensatory changes including increased production of ghrelin (the "hunger hormone") and decreased leptin levels

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In that analysis, regain after newer medicines such as semaglutide and tirzepatide averaged about 1.8 pounds per month, with projections suggesting many people could return close to their starting weight within about a year and a half