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These same cytokines play a central role in the pathogenesis of rheumatoid arthritis, where they contribute to joint inflammation, cartilage degradation, and bone erosion

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[47] Pregnancy [edit] Fetal valproate spectrum disorder (FVSD), previously known as fetal valproate syndrome (FVS), is a rare disease caused by prenatal exposure to valproic acid (VPA), a medication commonly used to treat epilepsy, bipolar disorder, and migraines