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There was no consistent pattern in the method used across the studies in the different brain regions

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Zhang K, Mikos AG, Reis RL, Zhang X

In particular, an RCT including 108 diabetic patients with mildmoderate ED demonstrated that a daily treatment with 5 g l-ARG plus 10 mg tadalafil, administered for 8 weeks, significantly improved ED assessed by IIEF-5 and testosterone levels, with a more significant improvement in both endpoints compared to patients receiving tadalafil or l-ARG as single compounds, whereas the significant improvements at basal and dynamic PDU were similar between groups [16]

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