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This change also reflects potential considerations regarding tolerability, clinical outcomes, and affordability

Clinical studies consistently show substantial weight loss outcomes in patients using GLP-1 medications, often accompanied by improvements in blood sugar control, cholesterol levels, and decreased cardiovascular risks

A variety of analyses (Table 2: scenario sets 1724) explored alternative assumptions about HbA1c thresholds triggering treatment intensification to basal and basal + bolus insulin regimens, as well as the extent to which interventional drugs were continued alongside insulin regimens prior to patient death

Peoples perceptions of weight and obesity likely play a strong role, too