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It has been shown using various atherosclerosis animal models that GLP-1RA therapy is associated with a reduction in atherosclerotic plaques, prevention of aorta intima-media thickening, improvement in vascular endothelial function, reduction of the necrotic zone and an increase of the fibrous component in the plaque and plaque stabilisation

A B12 self-injection pen is available as an option for patients who prefer it over a traditional syringe

High levels of body fat especially visceral fat surrounding internal organs increase the likelihood of insulin resistance and type 2 diabetes and contribute to hypertension, high cholesterol and an increased risk of cardiovascular diseases such as heart attack and stroke

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"The key question will be whether future research demonstrates a meaningful performance-enhancing effect independent of their therapeutic role in treating obesity and metabolic disease."