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These links reflect shared immunogenetic factors, including IL-18, IFN-, CTLA-4, HLA-DQ8, HLA-DQ2, HLA-B8, and HLA-DR3, many of which are integral to antigen presentation within the major histocompatibility complex (MHC)

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14 As stigma fades, these therapies are being reframed as holistic health tools, shifting consumption away from indulgence and toward intentionality