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Gastrointestinal Distress Despite its role in metabolism, B12 can sometimes irritate the stomach: Nausea Abdominal discomfort Loss of appetite 4

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Carnitine Metabolism Prior to engaging in the metabolic pathway with carnitine, long-chain fatty acids must first be activated to form acyl-CoA in a reaction catalyzed by acyl-CoA synthetase on the outer mitochondrial membrane [5]