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This is a form of dosage adjustment

Once the rats were killed, the colon was removed aseptically and placed on an ice-cold plate, longitudinally opened and the luminal contents were collected for the measurements of faecal moisture, pH and microbiological and SCFA production studies (see later)

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Here, we demonstrate that a peptideantibody conjugate that blocks GIPR while simultaneously activating GLP-1R (GIPR-Ab/GLP-1) requires both CNS GIPR and CNS GLP-1R for maximal weight loss in obese, primarily male, mice