These changes in components of appetite are suspected to be major contributors to the measured decrease in ad libitum food intake with tirzepatide compared with placebo
Proper medication storage directly impacts treatment outcomes, as degraded medication may deliver subtherapeutic doses, potentially leading to inadequate glycemic control or insufficient weight management effects
In summary, the formation of PYY is decreased by DPP-4 inhibition
But, it is important to keep in mind that excessive consumption or high dosages may lead to side effects
Activation of GLP-1R also promotes beta cell survival, inhibits gastric emptying, regulates food intake and reduces appetite (1, 5), making it a key pharmacological target for various metabolic disorders including type 2 diabetes (T2D) and obesity (6, 7)