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Description

Inflammatory cytokines, such as interleukin (IL)-1, IL-6, IL-18, and tumor necrosis factor- (TNF-), can be synthesized by different renal cells that plays a role in increasing the permeability of vascular endothelial cells, promoting the induction and differentiation of inflammatory cells, and activating apoptosis, thus promoting the development of DKD (25)

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Consequently, intracellular zinc homeostasis alterations regulate downstream molecular objectives, in addition to protein kinase C (PKC), ERK1/2 activation leading to neuronal cell death, cAMP-dependent protein kinase (PKA), Ca/calmodulin-dependent protein kinase II (CaMKII), phosphodiesterases (PDEs), protein tyrosine phosphatases (PTPs), and transcription factors, such as NF-B

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