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doi:10.1177/0091270006291622 152

Clementi A, Virzi GM, Brocca A, de Cal M, Vescovo G, Granata A, et al

Clinical studies show that kojic acid can reduce melanin synthesis by up to 80%, which translates to visible lightening of dark spots and overall skin tone

Furthermore, the activity of VEGF closely correlates with that of HIF-1 under hypoxic conditions, which further exacerbates inflammatory responses (23)

Other strengths included the use of objective measures of a range of cardiometabolic risk factors and comorbidities and a robust analytic approach incorporating propensity score methods to reduce potential confounding in the comparison of outcomes between treated and non-treated cohorts