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doi: 10.1038/s41586-021-04088-9 24 MencarelliMDubernBAliliRMaestriniSBenajibaLTagliaferriMet al

The injection would be administered into a pinched fold of skin right over that spot

Available at Accessed 11/10/21

Elevated hsCRP is an independent cardiovascular risk factor, and its reduction is considered a surrogate marker for improved cardiovascular outcomes Systolic blood pressure clinically meaningful reductions These improvements are consistent with but in several cases exceed the cardiometabolic benefits observed with semaglutide and tirzepatide in their respective Phase III programs

This pooled design eliminates inter-individual variability as a confounding factor and provides ten independent biological replicates (pool-based replicates) per treatment condition across the 10-week experimental period