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It was demonstrated that GLP-1 brain administration elevated the circulating concentrations of the adrenocorticotropic hormone (ACTH) and corticosterone and also enhanced anxiety in behavioral measurements [75]

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Histologically, schwannomas show strong S100 protein positivity and a biphasic pattern (Antoni A and B areas), while MPNSTs often have reduced or absent S100 expression , high mitotic activity, necrosis, and nuclear atypia