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Beyond redox regulation, GSH is involved in several essential cellular processes, including the synthesis of DNA and proteins, modulation of enzyme function, gene expression regulation, signal transduction, and both intracellular and transmembrane transport [13]

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Roughly 65 to 70 percent of women with PCOS have measurable insulin resistance, [2] and a 2025 systematic review confirmed that visceral fat distribution and insulin resistance are the strongest predictors of metabolic risk in this population stronger than BMI alone

Janese Laster, a gastroenterologist and obesity medicine specialist in Washington, D.C

These early safety signals prompted years of careful research into cancer risk with GLP-1 medications, including the newer dual-action drugs like Mounjaro