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How they work Alli and Xenical work to promote weight loss by blocking an enzyme called lipase

An 11% reduction in body weight over 28 days in a primate is substantial

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It is injected once weekly, and the timing relative to meals does not significantly impact its effectiveness

Long term safety lacking: Although there is very little evidence on the effects of melatonin on children, some experts believe that melatonin supplements can impact natural hormone development, which, in turn, impacts puberty and growth