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Studies have documented its capacity to stimulate collagen and glycosaminoglycan synthesis, accelerate wound healing, promote angiogenesis, exert antioxidant and anti-inflammatory effects, and modulate the expression of genes involved in tissue repair and regeneration

moreover, it increases the expression of vascular endothelial growth factor, which is a potent angiogenic factor, whereas tumor necrosis factor-, interleukin-6, and nuclear factor kappa B expression are inhibited, which benefits the healing of diabetic wounds (Qiang et al., 2017

The findings indicated that metformin treatment led to enhanced endometrial tolerance through the downregulation of tolerance-related miRNAs, specifically miR-1910-3p and miR-491-3p, resulting in elevated expression of endometrial tolerance markers HOXA10 and ITGB3 in patients with PCOS