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APE1 co-precipitates more with nucleophosmin (NPM1) in C9orf72 patient tissue lysates compared to controls (Farg et al., 2017), and overexpression of NPM1 inhibits apoptosis in neuronal cells expressing poly GR 100 and poly PR 100 (Farg et al., 2017)

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During this phase, insulin sensitivity declines 515% independent of age alone, accelerating weight gain and metabolic dysfunction