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similar changes can also be observed in various chronic inflammatory diseases and malignant tumors [192,193]
This remains an area of investigational interest rather than documented clinical application
302 Notably, microbial metabolites produced by commensal gut flora can limit pathogenic activities of microglia and astrocytes and suppress CNS inflammation in MS experimental models 303 and can contribute to the induction of specific LAMP1+TRAIL+ astrocytes that limit CNS inflammation by inducing T cell apoptosis
Lack of long-term safety data: As a relatively new compound, the long-term safety profile of Dihexa is not yet well-established
For OTA, the Klaassen equation has been used to estimate the continuous exposure to OTA based on blood plasma concentrations, and assumptions for plasma clearance and bioavailability (details in Duarte et al
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