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It has been reported that in renal tissue macrophages, the induction of glycolysis through the mTOR/HIF-1 signaling pathway exerts an inhibitory effect on inflammation and the recruitment of neutrophils mediated by immune complexes, underscoring its important role in diseases such as LN (157)

Also, decreased glutathione levels caused motor neuron degeneration in the hSOD1 wt over-expressing mice model (hemizygous mice over-expressing wild-type hSOD1 at moderate levels) (Killoy et al., 2018) and accelerated motor neuron death in SOD1 G93A mice (Pehar et al., 2014)

If taken along with diabetes medicines, it may cause blood sugar to drop too low

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However, clinical evidence in humans remains limited, and outcomes vary among individuals