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However, no large-scale RCT has tested the combined injectable formulation for weight loss

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Your clinician may suggest a nonhormonal menopausal treatment if you have a history of: stroke or blood clots (transdermal estrogen may be an option as studies do not show an increased risk with transdermal forms, like patches) some types of heart or liver problems, including a history of heart attack or unmanaged high blood pressure cancer that might be stimulated by hormones, like hormone-sensitive breast cancer Other contraindications include current pregnancy (yes, you can get pregnant while in perimenopause) and unexplained vaginal bleeding

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Enzymes such as superoxide dismuatase (SOD), catalase (CAT) and GPx can decompose ROS and prevent the damage to cellular constituents and initiation of lipid peroxidation