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Once activated, GLP-1 receptors trigger a cascade of effects: your pancreas releases more insulin (if blood sugar is elevated), your stomach empties more slowly, and your brain receives signals of fullness

Wegovys boxed warning states that semaglutide has caused thyroid tumors in animals, although its effects on humans are unclear

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PMID: 36462999 Contreras C et al (2017): Traveling from the hypothalamus to the adipose tissue: The thermogenic pathway