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Kidney Impairment Rybelsus should be used with caution in kidney impairment because nausea, vomiting, or diarrhea can lead to dehydration and may worsen kidney function

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Higher histamine in these organs and tissues leads to symptoms of headache and irritability (brain), red face, hot, sweaty, eczema, psoriasis and red lines if scratched (skin), increased heart rate (heart), difficulty breathing and asthma (lungs), increased utilization of methylation and nutrients which support methylation (liver)

doi: 10.1007/s002280050466 25 SzarfmanAMachadoSGO'NeillRT